The SNAPIN Polyclonal Antibody (CAB10294) is a high-quality antibody designed for research involving SNAPIN, a key protein involved in regulating vesicle trafficking and neurotransmitter release. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it a valuable tool for studying the function and localization of SNAPIN in various cellular processes.SNAPIN is a crucial component of the SNARE complex, which mediates vesicle fusion and neurotransmitter release in neurons. Dysregulation of SNAPIN has been implicated in neurodegenerative diseases, making it a promising target for therapeutic interventions. The SNAPIN Polyclonal Antibody enables researchers to study the expression levels and subcellular localization of SNAPIN in different cell types, providing insights into its role in neuronal function and potential implications in disease pathology.
This antibody is validated for use in Western blot applications, allowing for sensitive and specific detection of SNAPIN in cell lysates. Its high reactivity and specificity make it an excellent choice for studies focusing on synaptic transmission, neuronal signaling, and neurodegenerative disorders. By using the SNAPIN Polyclonal Antibody, researchers can advance their understanding of the molecular mechanisms underlying synaptic function and pathology, paving the way for the development of novel therapeutic approaches targeting SNAPIN-related pathways.
Product Name:
SNAPIN Rabbit Polyclonal Antibody
SKU:
CAB10294
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human SNAPIN (NP_036569.1).
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
23557
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SNAPIN Rabbit pAb (CAB10294) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
