Anti-SNAPC2 Antibody (CAB16069)
- SKU:
- CAB16069
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Anti-SNAPC2 Antibody (CAB16069)
The SNAPC2 Polyclonal Antibody (CAB16069) is a valuable tool for research focusing on SNAPC2, a critical subunit of the transcription initiation factor SNAPc complex. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in applications such as Western blotting. By binding to the SNAPC2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies in molecular biology and gene regulation.
SNAPC2 is essential for the initiation of transcription of snRNA genes, playing a crucial role in RNA polymerase II transcription. Its involvement in the regulation of gene expression makes it a key target for research in fields such as developmental biology, gene therapy, and RNA processing. Understanding the function of SNAPC2 is vital for unraveling the complexities of gene expression and transcriptional control mechanisms, leading to potential therapeutic insights and advancements in various genetic disorders.
| Antibody Name: | Anti-SNAPC2 Antibody |
| Antibody SKU: | CAB16069 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-100 of human SNAPC2 (NP_003074.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-100 of human SNAPC2 (NP_003074.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GPAT WSAR EKRQ LVRL LQAR QGQP EPDA TELA RELR GRSE AEIR VFLQ QLKG RVAR EAIQ KVHP GGLQ GPRR REAQ PPAP I |
| Gene ID: | 6618 |
| Uniprot: | Q13487 |
| Cellular Location: | Nucleus |
| Calculated MW: | 35kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SNAPC2, PTFDELTA, SNAP45 |
| Background: | This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SNAPC2: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19p13 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:transcription factor activity Biological Process: snRNA transcription; snRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription from RNA polymerase III promoter |
| NCBI Summary: | This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] |
| UniProt Code: | Q13487 |
| NCBI GenInfo Identifier: | 8134714 |
| NCBI Gene ID: | 6618 |
| NCBI Accession: | Q13487.1 |
| UniProt Secondary Accession: | Q13487,Q13486, B2RBZ6, D6W663, |
| UniProt Related Accession: | Q13487 |
| Molecular Weight: | 35,556 Da |
| NCBI Full Name: | snRNA-activating protein complex subunit 2 |
| NCBI Synonym Full Names: | small nuclear RNA activating complex polypeptide 2 |
| NCBI Official Symbol: | SNAPC2Â Â |
| NCBI Official Synonym Symbols: | SNAP45; PTFDELTAÂ Â |
| NCBI Protein Information: | snRNA-activating protein complex subunit 2 |
| UniProt Protein Name: | snRNA-activating protein complex subunit 2 |
| UniProt Synonym Protein Names: | Proximal sequence element-binding transcription factor subunit delta; PSE-binding factor subunit delta; PTF subunit delta; Small nuclear RNA-activating complex polypeptide 2; snRNA-activating protein complex 45 kDa subunit; SNAPc 45 kDa subunit |
| Protein Family: | snRNA-activating protein complex |
| UniProt Gene Name: | SNAPC2Â Â |
| UniProt Entry Name: | SNPC2_HUMAN |
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