The SNAP23 Polyclonal Antibody (CAB13909) is a specialized tool for researchers studying the SNAP23 protein, a key player in intracellular membrane fusion events. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it reliable for experiments such as Western blotting.SNAP23 is a member of the SNARE protein family and is involved in the fusion of vesicles with target membranes, essential for processes like neurotransmitter release and insulin-stimulated glucose uptake.
By targeting SNAP23, researchers can explore the mechanisms behind membrane trafficking and vesicle fusion in various cell types.The ability to detect and analyze SNAP23 with precision makes this polyclonal antibody an invaluable resource for studies in cell biology, neuroscience, and endocrinology. Understanding the functions of SNAP23 can provide insights into diseases like diabetes, neurodegenerative disorders, and immune system dysfunction, paving the way for new therapeutic approaches and drug targets.
Product Name:
SNAP23 Rabbit Polyclonal Antibody
SKU:
CAB13909
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human SNAP23 (NP_003816.2).
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
8773
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SNAP23 Rabbit pAb (CAB13909) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 2min.
