The SNAIL Family Transcriptional Repressor 2 (SNAI2) Polyclonal Antibody (CAB13352) is a vital tool for researchers studying the role of SNAI2 in cellular processes such as epithelial-mesenchymal transition (EMT) and cancer progression. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications.SNAI2, also known as Slug, is a key transcription factor involved in the regulation of gene expression, particularly in the context of EMT. By binding to SNAI2 protein, this antibody enables the detection and analysis of SNAI2 expression levels in a variety of cell types, making it an essential tool for studies in cancer biology and developmental biology.
The dysregulation of SNAI2 has been implicated in various diseases, including cancer metastasis and drug resistance. Therefore, understanding the function of SNAI2 at the molecular level is crucial for developing targeted therapies and diagnostic tools. The SNAI2 Polyclonal Antibody is a valuable resource for researchers seeking to elucidate the mechanisms underlying these pathological processes and identify novel therapeutic targets.
Product Name:
Slug Rabbit Polyclonal Antibody
SKU:
CAB13352
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 21-120 of human Slug (NP_003059.1).
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Purification Method:
Affinity purification
Gene ID:
6591
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Slug Rabbit pAb (CAB13352) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
