The SNAI1 Polyclonal Antibody (CAB5544) is a valuable tool for researchers studying SNAI1, a transcription factor involved in the regulation of epithelial to mesenchymal transition (EMT) and metastasis in cancer. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By targeting the SNAI1 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in cancer biology and metastasis research.SNAI1, also known as Snail, is a key regulator of EMT, a process involved in tumor progression and metastasis by promoting cells to acquire a mesenchymal phenotype. The aberrant expression of SNAI1 has been linked to tumor invasion and poor clinical outcomes in various cancer types.
Understanding the role of SNAI1 in EMT and metastasis is essential for developing targeted therapies to inhibit tumor progression and improve patient outcomes.The SNAI1 Polyclonal Antibody (CAB5544) offers researchers a reliable tool for investigating the role of SNAI1 in cancer biology, providing valuable insights into the mechanisms driving tumor metastasis. Its specificity and sensitivity make it a valuable asset for studies aimed at elucidating the molecular pathways involved in tumor progression and identifying potential therapeutic targets for combating cancer metastasis.
Product Name:
Snail Rabbit Polyclonal Antibody
SKU:
CAB5544
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-264 of human Snail (NP_005976.2).
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.
Purification Method:
Affinity purification
Gene ID:
6615
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Snail Rabbit pAb (CAB5544) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
