The SNAI1 Polyclonal Antibody (CAB11794) is a valuable tool for researchers studying SNAI1, a key transcription factor involved in epithelial-mesenchymal transition (EMT) and cancer metastasis. This antibody, developed using rabbit immunization, exhibits high specificity for human samples and has been validated for Western blot applications. By binding to the SNAI1 protein, it allows for precise detection and analysis in a variety of cell types, making it an essential resource for investigations in cancer biology and developmental biology.
SNAI1, also known as Snail, is a master regulator of EMT, a process that enables cancer cells to acquire invasive and metastatic properties. Its role in promoting tumor progression and metastasis makes it a valuable target for research into cancer therapeutics and biomarker development. Understanding the function of SNAI1 is critical for unraveling the mechanisms of cancer metastasis and identifying novel strategies for cancer treatment.
Product Name:
Snail Rabbit Polyclonal Antibody
SKU:
CAB11794
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-267 of human Snail (NP_005976.2).
293F transfected with Snail,HeLa,HCT 116,K-562,NIH/3T3
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
29kDa
Observed MW:
35kDa/29kDa/35kDa
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.
Purification Method:
Affinity purification
Gene ID:
6615
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with Snail using Snail Rabbit pAb (CAB11794) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 20μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
