The SMYD5 Antibody (PAC020561) is a valuable tool for researchers studying the SMYD5 protein, which plays a role in epigenetic regulation and gene expression. This polyclonal antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for Western blot applications. By binding to the SMYD5 protein, this antibody enables precise detection and analysis in a variety of cell types.SMYD5 is known to be involved in histone methylation and transcriptional regulation, making it a key player in the field of epigenetics and gene regulation.
Its significance in these pathways highlights its potential as a target for therapeutic interventions in diseases such as cancer, where aberrant gene expression and epigenetic changes can drive tumorigenesis.Understanding the function and activity of SMYD5 is essential for uncovering its role in cellular processes and identifying potential therapeutic strategies. The SMYD5 Antibody is a valuable tool for researchers looking to delve deeper into the molecular mechanisms underlying epigenetic regulation and gene expression.
Antibody Name:
SMYD5 Antibody (PACO20561)
Antibody SKU:
PACO20561
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SMYD5
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-4: HT29 cells, 231 cells, hela cells, A549 cells, Primary antibody: PACO20561(SMYD5 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
Background:
The SMYD (SET and MYND domain) family of lysine methyltransferases (KMTs) plays pivotal roles in various cellular processes, including gene expression regulation and DNA damage response. SMYD1, SMYD2, and SMYD3 share a high degree of sequence homology and, with the exception of SMYD5, human SMYD proteins harbor at least one C-terminal tetratrico peptide repeat (TPR) domain. The SMYD proteins have been found to be linked to various cancers and biological processes.
Synonyms:
SMYD family member 5
UniProt Protein Function:
SMYD5: Belongs to the class V-like SAM-binding methyltransferase superfamily
UniProt Protein Details:
Protein type:Methyltransferase; Methyltransferase, protein lysine; Transcription, coactivator/corepressor
