The SMURF2 Polyclonal Antibody (CAB10592) is a powerful tool for researchers studying the SMURF2 protein, a critical regulator of various cellular processes including protein degradation and cell proliferation. This antibody, raised in rabbits, exhibits high specificity and sensitivity for detecting SMURF2 in human samples, making it an essential tool for Western blot applications.SMURF2 plays a key role in the regulation of crucial signaling pathways involved in cell growth and differentiation. Dysregulation of SMURF2 has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases.
Therefore, understanding the function and regulation of SMURF2 is vital for developing targeted therapies to treat these conditions.With its ability to specifically detect SMURF2, the CAB10592 Polyclonal Antibody enables researchers to study the expression levels and localization of this protein in different cell types and tissues. By using this antibody, scientists can further explore the mechanisms underlying SMURF2-involved pathways, ultimately leading to advancements in drug development and personalized medicine.
Product Name:
SMURF2 Rabbit Polyclonal Antibody
SKU:
CAB10592
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 150-250 of human SMURF2 (NP_073576.1).
Enables SMAD binding activity; identical protein binding activity; and ubiquitin-protein transferase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent SMAD protein catabolic process. Located in nuclear speck. Part of ubiquitin ligase complex.
Purification Method:
Affinity purification
Gene ID:
64750
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of SW480 cells, using SMURF2 antibody (CAB10592) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
