The SMPD3 Polyclonal Antibody (CAB10197) is a crucial tool for researchers studying sphingomyelin phosphodiesterase 3 (SMPD3), an enzyme involved in sphingolipid metabolism and cell signaling pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot applications. By binding to the SMPD3 protein, researchers can detect and analyze its expression in various cell types, facilitating investigations in areas such as lipid metabolism, cell signaling, and neurodegenerative diseases.
SMPD3 is known to play a role in regulating intracellular levels of ceramide, a bioactive lipid that influences diverse cellular processes such as apoptosis, cell proliferation, and inflammation. Dysregulation of SMPD3 has been linked to neurodegenerative disorders, cardiovascular diseases, and cancer, highlighting its potential as a therapeutic target. The SMPD3 Polyclonal Antibody is an essential tool for researchers aiming to understand the functions of SMPD3 in health and disease, paving the way for the development of novel treatment strategies.
Product Name:
SMPD3 Rabbit Polyclonal Antibody
SKU:
CAB10197
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 416-655 of human SMPD3 (NP_061137.1).
Predicted to enable phosphatidic acid binding activity; phosphatidylserine binding activity; and sphingomyelin phosphodiesterase activity. Predicted to be involved in positive regulation of exosomal secretion and sphingomyelin metabolic process. Predicted to act upstream of or within several processes, including animal organ development; enzyme linked receptor protein signaling pathway; and sphingolipid metabolic process. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytoplasm. Biomarker of pulmonary emphysema.
Purification Method:
Affinity purification
Gene ID:
55512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SMPD3 Rabbit pAb (CAB10197) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
