Smox Antibody (PACO30008)
- SKU:
- PACO30008
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Smox Antibody (PACO30008)
The SMOX Antibody (PACO30008) is a polyclonal antibody designed for research involving the spermine oxidase (SMOX) protein. SMOX is an enzyme that plays a key role in polyamine catabolism, which has implications in various biological processes including cell growth, differentiation, and apoptosis. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot applications. It specifically binds to the SMOX protein, allowing for accurate detection and analysis in different cell types. This makes it an ideal tool for studies focusing on polyamine metabolism, cancer research, and other related fields.
The importance of SMOX in regulating polyamine levels and its potential role in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases make it a valuable target for research. Understanding the function and regulation of SMOX can provide valuable insights into the mechanisms underlying these conditions and aid in the development of novel therapeutic strategies. Overall, the SMOX Antibody is a valuable tool for researchers investigating the role of SMOX in various physiological and pathological processes, contributing to a better understanding of its potential implications in human health and disease.
| Antibody Name: | Smox Antibody (PACO30008) |
| Antibody SKU: | PACO30008 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Spermine oxidase protein (1-555AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. |
| Synonyms: | Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1), Smox, Smo |
| UniProt Protein Function: | SMOX: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. Belongs to the flavin monoamine oxidase family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.5.3.16 Cellular Component: cytoplasm; nucleus Molecular Function:oxidoreductase activity; polyamine oxidase activity Biological Process: polyamine catabolic process; spermine catabolic process |
| UniProt Code: | Q99K82 |
| NCBI GenInfo Identifier: | 295389670 |
| NCBI Gene ID: | 228608 |
| NCBI Accession: | NP_001171304.1 |
| UniProt Secondary Accession: | Q99K82,Q70LA3, Q70LA4, Q70LA5, Q70LA7, Q70LA8, Q70LA9 A2ANQ8, A2ANQ9, A2ANR0, A2ANR1, A2ANR2, |
| UniProt Related Accession: | Q99K82 |
| Molecular Weight: | 63.9 kDa |
| NCBI Full Name: | spermine oxidase isoform a |
| NCBI Synonym Full Names: | spermine oxidase |
| NCBI Official Symbol: | Smox  |
| NCBI Official Synonym Symbols: | PAO; SMO; PAOh1; B130066H01Rik  |
| NCBI Protein Information: | spermine oxidase |
| UniProt Protein Name: | Spermine oxidase |
| UniProt Synonym Protein Names: | Polyamine oxidase 1; PAO-1; PAOh1 |
| Protein Family: | Spermine oxidase |
| UniProt Gene Name: | Smox  |
| UniProt Entry Name: | SMOX_MOUSE |
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