SMG7 Rabbit Polyclonal Antibody (CAB15371)
- SKU:
- CAB15371
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | SMG7 Rabbit Polyclonal Antibody |
SKU: | CAB15371 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SMG7 (NP_963863.2). |
Sequence: | MSLQ SAQY LRQA EVLK ADMT DSKL GPAE VWTS RQAL QDLY QKML VTDL EYAL DKKV EQDL WNHA FKNQ ITTL QGQA KNRA NPNR SEVQ ANLS LFLE AASG FYTQ LLQE LCTV FNVD LPCR VKSS QLGI ISNK QTHT SAIV KPQS SSCS YICQ HCLV HLGD IARY RNQT SQAE SYYR HAAQ LVPS NGQP YNQL AILA SSKG DHLT TIFY YCRS IAVK FPFP AAST NLQK ALSK ALES RDEV KTKW GVSD FIKA FIKF HGHV YLSK SLEK LSPL REKL EEQF KRLL FQKA FNSQ QLVH VTVI |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | EST1C; SGA56M; C1orf16; SMG7 |
Positive Sample: | Jurkat,Mouse testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 127kDa |
Observed MW: | 127kDa |
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 9887 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |