The SMG6 Polyclonal Antibody (CAB10141) is specially designed for researchers studying SMG6, a key player in RNA surveillance pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications. By binding to the SMG6 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for investigations in molecular biology and RNA metabolism.SMG6, also known as a crucial component of the nonsense-mediated mRNA decay (NMD) pathway, plays a vital role in maintaining RNA integrity by degrading faulty transcripts.
Understanding the functions and mechanisms of SMG6 is essential for unraveling its involvement in genetic disorders, cancer, and other diseases related to RNA processing. By targeting SMG6 for research, scientists can advance their understanding of RNA surveillance pathways and potentially identify new therapeutic targets for various diseases.Overall, the SMG6 Polyclonal Antibody (CAB10141) is a reliable tool that allows researchers to explore the intricate functions of SMG6 in RNA metabolism, paving the way for advancements in the field of genetic research and disease therapeutics.
Product Name:
SMG6 Rabbit Polyclonal Antibody
SKU:
CAB10141
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1160-1419 of human SMG6 (NP_060045.4).
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
23293
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SMG6 antibody (CAB10141) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
