Anti-SMC6 Antibody (PACO20556)

Antibody Name:	SMC6 Antibody (PACO20556)
Antibody SKU:	PACO20556
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:20-1:100
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human SMC6

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20556(SMC6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane 1-4: Jurkat cells, 231 cells, hela cells, 293T cells, Primary antibody: PACO20556(SMC6 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20556(SMC6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:	Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene. Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.
Synonyms:	structural maintenance of chromosomes 6

UniProt Protein Function:	SMC6L1: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Belongs to the SMC family. SMC6 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA repair, damageChromosomal Location of Human Ortholog: 2p24.2Cellular Component: nucleoplasm; chromosome, telomeric region; PML body; nucleolus; intracellular; nucleusMolecular Function: protein binding; ATP bindingBiological Process: telomere maintenance via recombination; double-strand break repair via homologous recombination
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q96SB8
NCBI GenInfo Identifier:	122070455
NCBI Gene ID:	79677
NCBI Accession:	Q96SB8.2
UniProt Secondary Accession:	Q96SB8
UniProt Related Accession:	Q96SB8
Molecular Weight:	126kDa
NCBI Full Name:	Structural maintenance of chromosomes protein 6
NCBI Synonym Full Names:	structural maintenance of chromosomes 6
NCBI Official Symbol:	SMC6
NCBI Official Synonym Symbols:	SMC-6; hSMC6; SMC6L1
NCBI Protein Information:	structural maintenance of chromosomes protein 6
UniProt Protein Name:	Structural maintenance of chromosomes protein 6
UniProt Synonym Protein Names:
Protein Family:	Structural maintenance of chromosomes protein
UniProt Gene Name:	SMC6
UniProt Entry Name:	SMC6_HUMAN

Antibodies

SMC6 Antibody (PACO12341)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)