The SMC6 Antibody (PACO20555) is a highly specific polyclonal antibody designed for research involving SMC6, a key component of the structural maintenance of chromosomes (SMC) complex involved in DNA repair and genome stability. This antibody, raised in rabbits, is validated for use in various applications, particularly in Western blot and immunofluorescence.SMC6 is essential for maintaining chromosomal integrity and ensuring proper DNA replication and repair processes. Dysregulation of SMC6 has been linked to various diseases, including cancer and genetic disorders.
By targeting SMC6 with this antibody, researchers can investigate its function in different cell types and study its role in DNA damage response pathways.The SMC6 Antibody (PACO20555) offers a valuable tool for studying the molecular mechanisms underlying genome stability and DNA repair processes. Its high specificity and sensitivity make it an ideal choice for researchers working in the fields of genetics, cell biology, and cancer research. Explore the potential of SMC6 and uncover its significance in maintaining genomic integrity with this reliable antibody.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20555(SMC6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane 1-2: 293T cells, hela cells, Primary antibody: PACO20555(SMC6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20555(SMC6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene. Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.
Synonyms:
structural maintenance of chromosomes 6
UniProt Protein Function:
SMC6L1: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Belongs to the SMC family. SMC6 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA repair, damageChromosomal Location of Human Ortholog: 2p24.2Cellular Component: nucleoplasm; chromosome, telomeric region; PML body; nucleolus; intracellular; nucleusMolecular Function: protein binding; ATP bindingBiological Process: telomere maintenance via recombination; double-strand break repair via homologous recombination
