The SMC6 Polyclonal Antibody (PACO12341) is a valuable tool for researchers studying the SMC6 protein, a key component of the Structural Maintenance of Chromosomes (SMC) complex involved in DNA repair and genome stability. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.The SMC6 antibody specifically binds to the SMC6 protein, allowing for the detection and analysis of this important protein in various cell types. This makes it ideal for studies in molecular biology, genetics, and cancer research, where understanding the function of SMC6 is crucial for unraveling the mechanisms of DNA repair and maintaining genomic integrity.
Given the critical role of SMC6 in maintaining genomic stability, the SMC6 antibody holds promise for advancing our understanding of diseases related to DNA damage and mutations, such as cancer and genetic disorders. By enabling researchers to study the expression and function of SMC6, this antibody paves the way for the development of targeted therapies aimed at restoring genome stability and preventing disease progression.
structural maintenance of chromosomes 6;SMC6;FLJ22116;FLJ35534;SMC6L1 ;
UniProt Protein Function:
SMC6L1: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Belongs to the SMC family. SMC6 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA repair, damageChromosomal Location of Human Ortholog: 2p24.2Cellular Component: nucleoplasm; chromosome, telomeric region; PML body; nucleolus; intracellular; nucleusMolecular Function: protein binding; ATP bindingBiological Process: telomere maintenance via recombination; double-strand break repair via homologous recombination
