The SMC5 Polyclonal Antibody (CAB2301) is a valuable tool for researchers studying the SMC5 protein, which is part of the structural maintenance of chromosomes (SMC) complex involved in DNA repair and genome stability. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SMC5 protein, this antibody allows for the detection and analysis of SMC5 expression in various cell types, making it ideal for studies in genetics, cell biology, and cancer research.
SMC5 is essential for maintaining the integrity of the genome by ensuring proper chromosome segregation and DNA repair. Dysregulation of SMC5 has been implicated in various genetic disorders and cancers, highlighting its importance in maintaining genome stability. By understanding the function and regulation of SMC5, researchers can gain insights into the mechanisms of DNA repair and potentially identify new targets for therapeutic interventions in cancer and genetic diseases.
Product Name:
SMC5 Rabbit Polyclonal Antibody
SKU:
CAB2301
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 872-1101 of human SMC5 (NP_055925.2).
Predicted to enable ATP binding activity. Involved in several processes, including DNA recombination; cellular senescence; and positive regulation of maintenance of mitotic sister chromatid cohesion. Located in cell junction; chromosome; and nuclear body. Part of Smc5-Smc6 complex.
Purification Method:
Affinity purification
Gene ID:
23137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SMC5 Rabbit pAb (CAB2301) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
