The SMC4 Polyclonal Antibody (CAB13933) is specifically designed for research involving the SMC4 protein, a key component of the Structural Maintenance of Chromosomes (SMC) complex. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunohistochemistry applications.SMC4 is essential for proper chromosome segregation and DNA repair processes during cell division. Dysregulation of SMC4 has been implicated in various diseases, including cancer and genetic disorders. The SMC4 Polyclonal Antibody allows for the detection and analysis of SMC4 protein expression in different cell types, facilitating research in cell biology, oncology, and genetic studies.
Understanding the function and regulation of SMC4 is crucial for advancing our knowledge of chromosome dynamics and identifying potential therapeutic targets for diseases associated with chromosomal instability. The SMC4 Polyclonal Antibody is a valuable tool for researchers investigating the role of SMC4 in genome maintenance and chromatin organization.
Product Name:
SMC4 Rabbit Polyclonal Antibody
SKU:
CAB13933
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMC4 (NP_001275682.1).
This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2.
Purification Method:
Affinity purification
Gene ID:
10051
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SMC4 Rabbit pAb (CAB13933) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3s.
