The SMC3 Polyclonal Antibody (CAB18402) is a valuable tool for researchers studying the SMC3 protein, a key component of the cohesin complex involved in chromosome segregation and DNA repair processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to SMC3, researchers can accurately detect and analyze the protein in various cell types, making it suitable for studies in genetics, cell biology, and cancer research.SMC3 plays a crucial role in maintaining genomic stability by ensuring proper chromosome alignment and segregation during cell division.
Dysregulation of SMC3 has been linked to various genetic disorders and cancer development, highlighting its importance in cellular processes. Research into the functions and mechanisms of SMC3 is essential for advancing our understanding of genetic diseases and identifying potential therapeutic targets for cancer treatment.Overall, the SMC3 Polyclonal Antibody is a reliable tool for investigating the role of SMC3 in chromosomal integrity and DNA repair, providing valuable insights into the molecular mechanisms underlying genetic disorders and cancer progression.
Product Name:
SMC3 Rabbit Polyclonal Antibody
SKU:
CAB18402
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 909-1199 of human SMC3 (NP_005436.1).
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
Purification Method:
Affinity purification
Gene ID:
9126
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SMC3 Rabbit pAb (CAB18402) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
