SMC1 Rabbit Monoclonal Antibody (CAB4693)
- SKU:
- CAB4693
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CDLS2
- DXS423E
- SB1.8
- SMC1
- SMC1L1
- SMC1alpha
- SMCB
- Research Area:
- Cell Cycle
Description
Product Name: | SMC1 Rabbit Monoclonal Antibody |
SKU: | CAB4693 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1134-1233 of human SMC1 (Q14683). |
Sequence: | TVAA LALL FAIH SYKP APFF VLDE IDAA LDNT NIGK VANY IKEQ STCN FQAI VISL KEEF YTKA ESLI GVYP EQGD CVIS KVLT FDLT KYPD ANPN PNEQ |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | SMC1; SMCB; CDLS2; DEE85; SB1.8; EIEE85; SMC1L1; DXS423E; SMC1alpha |
Positive Sample: | HeLa,293T,Jurkat,Mouse lung,Mouse brain,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, Centromere, Kinetochore. |
Calculated MW: | 143kDa |
Observed MW: | 160kDa |
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 8243 |
Clone Number: | ARC1095 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |