The SMARCE1 Polyclonal Antibody (CAB5361) is a high-quality research tool designed for studying the SMARCE1 protein, an essential component of the SWI/SNF chromatin remodeling complex. This antibody, raised in rabbits, has been validated for use in various applications, including Western blotting and immunofluorescence.SMARCE1, also known as BAF57, plays a key role in chromatin remodeling and gene regulation, making it a crucial player in diverse biological processes such as development, differentiation, and tumorigenesis. By targeting SMARCE1 with this antibody, researchers can accurately detect and analyze the protein in different cell types, making it an ideal tool for studies in molecular biology and cancer research.
Understanding the function and regulation of SMARCE1 is essential for unraveling its involvement in various diseases, including cancer and developmental disorders. By using the SMARCE1 Polyclonal Antibody, researchers can delve deeper into the intricate mechanisms of chromatin remodeling and gene expression, contributing to advancements in personalized medicine and targeted therapies.
Product Name:
BAF57/SMARCE1 Rabbit Polyclonal Antibody
SKU:
CAB5361
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-411 of human BAF57/BAF57/SMARCE1 (NP_003070.3).
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
Purification Method:
Affinity purification
Gene ID:
6605
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using BAF57/SMARCE1 Rabbit pAb (CAB5361) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
