The SMARCB1 (SNF5) Polyclonal Antibody (CAB10006) is a versatile tool for research involving the SMARCB1 protein, also known as SNF5, a core subunit of the SWI/SNF chromatin remodeling complex. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to SMARCB1, this antibody enables the detection and analysis of the protein in various cell types, making it well-suited for studies in cancer biology and epigenetics.SMARCB1 plays a crucial role in the regulation of gene expression by modulating chromatin structure, thereby influencing various cellular processes such as proliferation, differentiation, and DNA repair.
Dysregulation of SMARCB1 has been implicated in the development of certain cancers, making it a potential target for therapeutic interventions. Research utilizing the SMARCB1 Polyclonal Antibody can provide valuable insights into the molecular mechanisms underlying cancer progression and may contribute to the development of novel treatments targeting SWI/SNF complex dysfunction in cancer.
Product Name:
SMARCB1/SNF5 Polyclonal Antibody
SKU:
CAB21826
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human SMARCB1/SNF5 (NP_003064.2).
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6598
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SMARCB1/SNF5 Rabbit pAb (CAB21826) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
