The SMARCB1 Polyclonal Antibody (CAB5767) is a valuable tool for researchers studying SMARCB1, a protein involved in chromatin remodeling and gene regulation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to SMARCB1, this antibody allows for the detection and analysis of this important protein in a variety of cell types, making it ideal for studies in epigenetics, cancer research, and developmental biology.SMARCB1, also known as INI1, is a key player in the SWI/SNF chromatin remodeling complex, which regulates gene expression by altering the structure of chromatin.
Mutations in SMARCB1 are associated with a variety of cancers and developmental disorders, making it an important target for research into disease mechanisms and potential therapeutic interventions. Understanding the role of SMARCB1 in chromatin dynamics is crucial for unraveling the complexities of gene regulation and cellular differentiation.Overall, the SMARCB1 Polyclonal Antibody (CAB5767) offers researchers a powerful tool for investigating the role of SMARCB1 in various biological processes and disease states. Its high specificity and reliability make it a valuable asset in the quest for new insights into chromatin remodeling and gene regulation.
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6598
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SMARCB1/SNF5 Rabbit pAb (CAB5767) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
