The SMARCA5 Polyclonal Antibody (CAB2000) is a valuable tool for researchers studying SMARCA5, a member of the SWI/SNF chromatin remodeling complex involved in gene regulation and DNA repair. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting SMARCA5 in human samples, making it suitable for Western blot analysis.SMARCA5, also known as SNF2H, is essential for the proper functioning of the SWI/SNF complex, which plays a critical role in chromatin remodeling and gene expression. Dysregulation of SMARCA5 has been implicated in various diseases, including cancer, developmental disorders, and neurological conditions.
Therefore, understanding the function and regulation of SMARCA5 is important for unraveling its role in these pathologies and potentially identifying therapeutic targets.By utilizing the SMARCA5 Polyclonal Antibody (CAB2000), researchers can further investigate the biological functions of SMARCA5 in different cellular contexts and disease models. This antibody enables precise detection and analysis of SMARCA5 levels, allowing for a deeper understanding of its role in chromatin remodeling and gene transcription. Ultimately, this antibody serves as a valuable tool for advancing research in fields such as cancer biology, epigenetics, and gene regulation.
Product Name:
SMARCA5/SNF2H Rabbit Polyclonal Antibody
SKU:
CAB2000
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human SMARCA5/SNF2H (NP_003592.3).
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.
Purification Method:
Affinity purification
Gene ID:
8467
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SMARCA5/SNF2H antibody (CAB2000) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 2min.
