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[KO Validated] BRG1/SMARCA4 Rabbit Polyclonal Antibody (CAB0887)

SKU:
CAB0887
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Neuroscience
  • KO Validated Antibodies 1 Anti-SMARCA4 Antibody CAB0887KO Validated
  • KO Validated Antibodies 1 Anti-SMARCA4 Antibody CAB0887KO Validated
  • KO Validated Antibodies 1 Anti-SMARCA4 Antibody CAB0887KO Validated
  • KO Validated Antibodies 1 Anti-SMARCA4 Antibody CAB0887KO Validated
  • KO Validated Antibodies 1 Anti-SMARCA4 Antibody CAB0887KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] BRG1/SMARCA4 Rabbit Polyclonal Antibody
SKU:CAB0887
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 30-130 of human BRG1/BRG1/SMARCA4 (NP_003063.2).
Sequence:PSPG PSPG SAHS MMGP SPGP PSAG HPIP TQGP GGYP QDNM HQMH KPME SMHE KGMS DDPR YNQM KGMG MRSG GHAG MGPP PSPM DQHS QGYP SPLG GSEH A
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:20 - 1:50
Synonyms:BRG1; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; SNF2-beta; A4
Positive Sample:OVCAR3,HeLa
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:185kDa
Observed MW:180kDa

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:6597
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using BRG1/BRG1/SMARCA4 antibody (CAB0887) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.

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