The Smad9 Polyclonal Antibody (CAB7518) is a vital tool for researchers studying the Smad9 protein, a key regulator in the TGF-β signaling pathway. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Smad9 protein, this antibody allows for the detection and analysis of Smad9 expression in various cell types, making it ideal for studies in cell biology and cancer research.Smad9 is a transcription factor that plays a crucial role in mediating the downstream effects of TGF-β signaling, including cell growth, differentiation, and apoptosis.
Dysregulation of the TGF-β signaling pathway, including aberrant Smad9 activity, has been implicated in various diseases such as cancer, fibrosis, and immune disorders. Therefore, studying the function of Smad9 and its interaction with other signaling molecules is essential for understanding the molecular mechanisms underlying these pathological conditions and developing targeted therapies.
Product Name:
SMAD9 Rabbit Polyclonal Antibody
SKU:
CAB7518
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human Smad9 (NP_005896.1).
The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4093
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human liver cancer using Smad9 Rabbit pAb (CAB7518) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
