Smad7 Rabbit Polyclonal Antibody (CAB12343)
- SKU:
- CAB12343
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | Smad7 Rabbit Polyclonal Antibody |
SKU: | CAB12343 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 220-420 of human Smad7 (NP_005895.1). |
Sequence: | KPTA DCPD AVPS SAET GGTN YLAP GGLS DSQL LLEP GDRS HWCV VAYW EEKT RVGR LYCV QEPS LDIF YDLP QGNG FCLG QLNS DNKS QLVQ KVRS KIGC GIQL TREV DGVW VYNR SSYP IFIK SATL DNPD SRTL LVHK VFPG FSIK AFDY EKAY SLQR PNDH EFMQ QPWT GFTV QISF VKGW GQCY TRQF ISSC PCWL E |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | CRCS3; MADH7; MADH8; Smad7 |
Positive Sample: | ECV-304,A-549,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 46kDa |
Observed MW: | 50kDa |
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 4092 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |