The SMAD6 Polyclonal Antibody (CAB14749) is a valuable tool for researchers studying the SMAD6 protein, a key regulator in the TGF-β signaling pathway. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for Western blot applications. By binding specifically to SMAD6, this antibody enables accurate detection and analysis in a variety of cell types.SMAD6 is known for its role in inhibiting TGF-β signaling, ultimately regulating cell growth, differentiation, and apoptosis. Dysregulation of this pathway has been implicated in various diseases, including cancer, fibrosis, and immune disorders.
By studying SMAD6 with the use of this antibody, researchers can gain insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets.With its reliability and specificity, the SMAD6 Polyclonal Antibody (CAB14749) is a valuable tool for advancing research in molecular biology, immunology, and oncology. Researchers can trust in the quality and performance of this antibody to support their investigations into the function and regulation of SMAD6 in health and disease.
Product Name:
Smad6 Rabbit Polyclonal Antibody
SKU:
CAB14749
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 257-496 of human Smad6 (NP_005576.3).
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4091
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Smad6 antibody (CAB14749) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
