The Smad6 Polyclonal Antibody (CAB0579) is a powerful tool for researchers studying Smad6, a key protein involved in regulating the TGF-beta signaling pathway. This antibody, produced in rabbits, shows high specificity and sensitivity towards human samples and is well-suited for use in Western blot applications. By targeting the Smad6 protein, this antibody allows for accurate detection and analysis of Smad6 expression in various cell types, making it an essential asset for studies in molecular biology and cancer research.Smad6 is known for its role in negatively regulating TGF-beta signaling, a pathway that plays a crucial role in cell growth, differentiation, and immune response.
Dysregulation of the TGF-beta pathway has been linked to various diseases, including cancer, fibrosis, and autoimmune disorders. By exploring the function of Smad6, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.Overall, the Smad6 Polyclonal Antibody (CAB0579) offers researchers a reliable tool for investigating the role of Smad6 in cellular processes and disease development. Its high specificity and versatility make it an invaluable resource for advancing our understanding of TGF-beta signaling and its implications for human health.
Product Name:
Smad6 Rabbit Polyclonal Antibody
SKU:
CAB0579
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 257-496 of human Smad6 (NP_005576.3).
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4091
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Smad6 antibody (CAB0579) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
