The SMAD6 Polyclonal Antibody is a valuable tool for researchers studying the SMAD6 protein, which plays a crucial role in the regulation of the TGF-beta signaling pathway. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications.SMAD6 is a key regulator of TGF-beta signaling, a pathway involved in various cellular processes including cell growth, differentiation, and apoptosis. Dysregulation of this pathway has been implicated in numerous diseases, including cancer and fibrosis.
The ability to accurately detect and analyze SMAD6 expression levels in different cell types provides researchers with valuable insights into the mechanisms underlying these pathologies.By utilizing the SMAD6 Polyclonal Antibody in their research, scientists can further our understanding of the role of SMAD6 in disease development and progression. This knowledge could potentially lead to the development of novel therapeutics targeting the TGF-beta signaling pathway, offering new hope for patients affected by TGF-beta-related disorders.
Product Name:
Smad6 Polyclonal Antibody
SKU:
CAB24035
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 231-330 of human Smad6 (NP_005576.3).
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4091
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and Smad6 knockdown (KD) HeLa cells using [KD Validated]Smad6 Rabbit pAb (CAB24035) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
