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Smac/Diablo Rabbit Monoclonal Antibody (CAB8889)

SKU:
CAB8889
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Death
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Smac/Diablo Rabbit Monoclonal Antibody
SKU:CAB8889
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 56-239 of human Smac/Diablo (NP_063940.1).
Sequence:AVPI AQKS EPHS LSSE ALMR RAVS LVTD STST FLSQ TTYA LIEA ITEY TKAV YTLT SLYR QYTS LLGK MNSE EEDE VWQV IIGA RAEM TSKH QEYL KLET TWMT AVGL SEMA AEAA YQTG ADQA SITA RNHI QLVK LQVE EVHQ LSRK AETK LAEA QIEE LRQK TQEE GEER AESE QEAY LRED
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:SMAC; DFNA64; Smac/Diablo
Positive Sample:SP2/0,HeLa,MCF7,C2C12,Jurkat,C6,Mouse heart,Rat lung,Rat testis
Conjugate:Unconjugated
Cellular Localization:Mitochondrion.
Calculated MW:27kDa/21kDa/22kDa
Observed MW:19kDa

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.

Purification Method:Affinity purification
Gene ID:56616
Clone Number:ARC1340
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Smac/Diablo Rabbit mAb (CAB8889) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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