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SMAC/DIABLO Monoclonal Antibody [PAT19F2A] (CPAB0589)

SKU:
CPAB0589
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT19F2A
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

SMAC/DIABLO Monoclonal Antibody [PAT19F2A] (CPAB0589)

The SMAC/Diablo Antibody (CPAB0589) is a valuable tool for researchers studying apoptotic pathways and cell death mechanisms. This rabbit polyclonal antibody is highly specific for the SMAC/Diablo protein and is validated for use in Western blot applications. SMAC/Diablo, also known as Second Mitochondria-derived Activator of Caspases, is a key regulator of apoptosis by promoting caspase activation and inhibiting inhibitors of apoptosis proteins (IAPs). Dysregulation of SMAC/Diablo has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions.

By detecting and analyzing SMAC/Diablo protein expression in various cell types, this antibody is essential for investigating the role of SMAC/Diablo in disease pathology and developing targeted therapies. Its high specificity and reactivity with human samples make it a valuable asset for researchers in the fields of cell biology, cancer research, and immunology.

Product Name:SMAC/DIABLO Antibody
Product Sku:CPAB0589
Size:5μg
Host Species:Mouse
Immunogen:Anti-human SMAC/DIABLO mAb, clone PAT19F2A, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SMAC/DIABLO protein 56-239 amino acids  purified from Ecoli.
Clone:PAT19F2A.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:SMAC/DIABLO antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:Smac/Diablo is a proapoptotic protein that increases caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by its binding to the inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. Smac/Diablo is a mitochondrial protein which enters the cytosol when cells go through apoptosis, and it moderates the caspase inhibition of IAPs.Smac/DIABLO expression is associated with the result of renal cell carcinoma.Dimeric form of Smac/DIABLO implies that once expressed in the cell the protein has a little probability of dissociation and, thus, loss of function. Survivin, Smac/DIABLO, & PKC-? play an important part in the inhibition of apoptosis by FGF-2 in human small cell lung cancer cells. Mitochondrial survivin associates with Smac/DIABLO, delaying its release. Decreased expression of Smac protein takes part in ovarian carcinogenesis and chemotherapeutic resistance. Smac/DIABLO plays a role in tumor cells during the pathway of apoptosis induction. SMAC protein is regulated by XIAP and degraded by proteasome. SMAC protein takes part inleukemic cell apoptosis. Smac is released during stress-induced apoptosis in multiple myeloma cells.
Synonyms:Diablo homolog mitochondrial, Second mitochondria-derived activator of caspase, Smac protein, Direct IAP-binding protein with low pI, DIABLO, SMAC, SMAC3, DIABLO-S, FLJ10537, FLJ25049.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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