The SLITRK5 Polyclonal Antibody (PAC051966) is a valuable tool for researchers studying SLITRK5, a member of the SLITRK family of proteins involved in neuronal development and function. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically recognizes and binds to the SLITRK5 protein, allowing for its detection and analysis in various experimental settings.SLITRK5 has been implicated in various neurological disorders, including Tourette syndrome and obsessive-compulsive disorder, highlighting its importance in brain function and behavior.
By studying the role of SLITRK5 using this antibody, researchers can gain insights into the molecular mechanisms underlying these disorders and potentially identify novel therapeutic targets.Overall, the SLITRK5 Polyclonal Antibody is an essential tool for investigating the function of SLITRK5 in the nervous system and advancing our understanding of its implications in neurological conditions. Its specificity and reliability make it a valuable asset for neuroscientists and researchers interested in synaptic development and neuronal signaling pathways.
Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: SLITRK5 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 108, 80 kDa. Observed band size: 108 kDa..
Immunocytochemistry analysis of human lung cancer using PACO51966 at dilution of 1:100.
Immunohistochemistry analysis of human testis tissue using PACO51966 at dilution of 1:100.
Background:
Suppresses neurite outgrowth.
Synonyms:
SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11), SLITRK5, KIAA0918 LRRC11
UniProt Protein Function:
SLITRK5: Suppresses neurite outgrowth. Belongs to the SLITRK family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 13q31.2Cellular Component: integral to membrane; receptor complexBiological Process: skin development; grooming behavior; synaptic transmission; response to xenobiotic stimulus; axonogenesis; striatum development; dendrite morphogenesis; adult behavior
UniProt Protein Details:
NCBI Summary:
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
