The SLITRK3 Polyclonal Antibody (PACO12314) is a valuable tool for researchers studying SLITRK3, a neuronal protein involved in synaptic signaling and neuronal development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SLITRK3 protein, this antibody allows for the detection and analysis of SLITRK3 expression in various cell types, making it an ideal choice for studies in neuroscience and neurodevelopmental disorders.SLITRK3 is a transmembrane protein that plays a key role in mediating neuronal communication and synaptic plasticity, making it a crucial target for investigation in neurological research.
Its involvement in the development and function of neuronal circuits highlights its potential significance in conditions such as autism spectrum disorders, schizophrenia, and other neurodevelopmental disorders. Understanding the functions of SLITRK3 is essential for unraveling the complexities of neuronal connectivity and may lead to potential therapeutic interventions for these disorders.
SLIT and NTRK-like family, member 3;SLITRK3;KIAA0848;MGC138681 ;
UniProt Protein Function:
SLITRK3: Suppresses neurite outgrowth. Belongs to the SLITRK family.Protein type: Membrane protein, integral; Cell surfaceChromosomal Location of Human Ortholog: 3q26.1Cellular Component: integral to membraneBiological Process: axonogenesis
UniProt Protein Details:
NCBI Summary:
Members of the SLITRK family, such as SLITRK3, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK3, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
