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SLCO1B3 Antibody (PACO48758)

SKU:
PACO48758
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SLCO1B3 Antibody PACO48758
  • SLCO1B3 Antibody PACO48758
  • SLCO1B3 Antibody PACO48758
€359

Description

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SLCO1B3 Antibody (PACO48758)

The SLCO1B3 Antibody (PAC048758) is a highly specific tool for researchers studying the SLCO1B3 protein, an important transporter involved in the uptake and elimination of drugs and endogenous compounds. This polyclonal antibody, produced in rabbits, is optimized for detecting SLCO1B3 in human samples and has been validated for use in Western blot applications.SLCO1B3, also known as organic anion transporting polypeptide 1B3, is primarily expressed in the liver and plays a crucial role in drug metabolism and disposition. Its function in transporting a wide range of substrates makes it a key player in drug-drug interactions and personalized medicine approaches.

By targeting SLCO1B3, researchers can gain insights into drug transport mechanisms, pharmacokinetics, and potential therapeutic strategies for liver diseases and cancer.This SLCO1B3 Antibody provides researchers with a reliable tool for investigating the expression and function of SLCO1B3 in various experimental settings, including cell culture models and tissue samples. Its specificity and sensitivity make it an invaluable resource for studies aiming to understand the role of SLCO1B3 in drug transport, liver physiology, and the development of targeted therapies for liver-related disorders.

Antibody Name:SLCO1B3 Antibody (PACO48758)
Antibody SKU:PACO48758
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Solute carrier organic anion transporter family member 1B3 protein (648-695AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human liver tissue using PACO48758 at dilution of 1:100.
Product ImageImmunofluorescent analysis of HepG2 cells using PACO48758 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human liver cancer using PACO48758 at dilution of 1:100.
Background:Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acid, and organic anions from the liver.
Synonyms:Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8), SLCO1B3, LST2 OATP1B3 OATP8 SLC21A8
UniProt Protein Function:SLCO1B3: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP).Involved in the clearance of bile acids and organic anions from the liver. Defects in SLCO1B3 are a cause of hyperbilirubinemia, Rotor type (HBLRR). An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Belongs to the organo anion transporter (TC 2.A.60) family.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; TransporterChromosomal Location of Human Ortholog: 12p12Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: bile acid transmembrane transporter activity; organic anion transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activityBiological Process: bile acid and bile salt transport; bile acid metabolic process; organic anion transport; sodium-independent organic anion transportDisease: Hyperbilirubinemia, Rotor Type
UniProt Protein Details:
NCBI Summary:This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]
UniProt Code:Q9NPD5
NCBI GenInfo Identifier:27734563
NCBI Gene ID:28234
NCBI Accession:Q9NPD5.1
UniProt Secondary Accession:Q9NPD5,Q5JAR4, E7EMT8
UniProt Related Accession:Q9NPD5
Molecular Weight:82,544 Da
NCBI Full Name:Solute carrier organic anion transporter family member 1B3
NCBI Synonym Full Names:solute carrier organic anion transporter family member 1B3
NCBI Official Symbol:SLCO1B3  
NCBI Official Synonym Symbols:LST3; HBLRR; LST-2; OATP8; OATP-8; OATP1B3; SLC21A8; LST-3TM13  
NCBI Protein Information:solute carrier organic anion transporter family member 1B3
UniProt Protein Name:Solute carrier organic anion transporter family member 1B3
UniProt Synonym Protein Names:Liver-specific organic anion transporter 2; LST-2; Organic anion transporter 8; Organic anion-transporting polypeptide 8; OATP-8; Solute carrier family 21 member 8
Protein Family:Solute carrier organic anion transporter family
UniProt Gene Name:SLCO1B3  
UniProt Entry Name:SO1B3_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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