The SLCO1B1 Polyclonal Antibody (CAB15783) is a valuable tool for researchers studying SLCO1B1, a cell surface transporter involved in the uptake of drugs and endogenous compounds in the liver. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blotting.SLCO1B1, also known as OATP1B1, plays a crucial role in drug metabolism and drug-drug interactions, making it a key target for pharmacological studies. Its expression in the liver affects the pharmacokinetics of numerous drugs, including statins and anticancer agents.
Understanding the function and regulation of SLCO1B1 is essential for optimizing drug therapies and predicting drug responses in patients.The SLCO1B1 Polyclonal Antibody enables researchers to detect and analyze SLCO1B1 protein expression in different cell types, providing valuable insights into its role in drug transport and metabolism. This antibody is an essential tool for studies focusing on personalized medicine, pharmacogenomics, and drug development.
Product Name:
SLCO1B1 Rabbit Polyclonal Antibody
SKU:
CAB15783
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 597-691 of human SLCO1B1 (NP_006437.3).
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.
Purification Method:
Affinity purification
Gene ID:
10599
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLCO1B1 Rabbit pAb (CAB15783) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
