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Anti-SLCO1A2 Antibody (CAB8452)

SKU:
CAB8452
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
€139 - €419
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Description

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Antibody Name:Anti-SLCO1A2 Antibody
Antibody SKU:CAB8452
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 606-670 of human SLCO1A2 (NP_602307.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, HeLa, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 606-670 of human SLCO1A2 (NP_602307.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AALR GSSF VPAL IILI LLRK CHLP GENA SSGT ELIE TKVK GKEN ECKD IYQK STVL KDDE LKTK L
Gene ID:6579
Uniprot:P46721
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:64kDa/74kDa
Observed MW:60kDa
Synonyms:SLCO1A2, OATP, OATP-A, OATP1A2, SLC21A3
Background:This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:SLCO1A2: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. Selectively inhibited by the grapefruit juice component naringin. Belongs to the organo anion transporter (TC 2.A.60) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: integral to membrane; plasma membrane

Molecular Function:organic anion transmembrane transporter activity

Biological Process: bile acid and bile salt transport; sodium-independent organic anion transport; bile acid metabolic process; transmembrane transport; organic anion transport

NCBI Summary:This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
UniProt Code:P46721
NCBI GenInfo Identifier:10835099
NCBI Gene ID:6579
NCBI Accession:NP_066580.1
UniProt Secondary Accession:P46721,Q9UGP7, Q9UL38,
UniProt Related Accession:P46721
Molecular Weight:74,145 Da
NCBI Full Name:solute carrier organic anion transporter family member 1A2
NCBI Synonym Full Names:solute carrier organic anion transporter family, member 1A2
NCBI Official Symbol:SLCO1A2  
NCBI Official Synonym Symbols:OATP; OATP-A; OATP1A2; SLC21A3  
NCBI Protein Information:solute carrier organic anion transporter family member 1A2; OATP-1; solute carrier family 21 member 3; organic anion transporting polypeptide A; organic anion-transporting polypeptide 1; sodium-independent organic anion transporter; solute carrier family
UniProt Protein Name:Solute carrier organic anion transporter family member 1A2
UniProt Synonym Protein Names:OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3
UniProt Gene Name:SLCO1A2  
UniProt Entry Name:SO1A2_HUMAN
Anti-SLCO1A2 Polyclonal Antibody (CAB8452)Western blot analysis of extracts of various cell lines, using SLCO1A2 antibody (CAB8452) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

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