The SLCO1A2 Polyclonal Antibody (CAB8452) is a valuable tool for researchers studying the SLCO1A2 protein, a member of the organic anion transporting polypeptide family involved in the transport of various endogenous and exogenous substances across cell membranes. This antibody, produced in rabbits, reacts specifically with human samples and is validated for use in Western blot applications.SLCO1A2 plays a crucial role in drug absorption, distribution, and elimination, making it a target of interest in pharmacology and drug metabolism studies. By detecting and analyzing the SLCO1A2 protein in different cell types, researchers can gain insight into its function and potential implications for drug transport and metabolism.
The SLCO1A2 Polyclonal Antibody is an essential tool for researchers in pharmacology, drug development, and toxicology seeking to understand the role of SLCO1A2 in drug transport and metabolism processes. Its high specificity and reactivity with human samples make it a reliable choice for studies investigating the mechanisms underlying drug interactions and pharmacokinetics.
Product Name:
SLCO1A2 Rabbit Polyclonal Antibody
SKU:
CAB8452
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human SLCO1A2 (NP_066580.1).
Sequence:
SYEG IPQD LYVE NDIF ADC
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:1000 - 1:5000
Synonyms:
OATP; OATP-A; OATP1A2; SLC21A3; SLCO1A2
Positive Sample:
Rat liver
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Multi-pass membrane protein.
Calculated MW:
74kDa
Observed MW:
74kDa
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6579
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat liver, using SLCO1A2 Rabbit pAb (CAB8452) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
