| UniProt Protein Function: | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. |
| NCBI Summary: | This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q15599 |
| NCBI GenInfo Identifier: | 194018553 |
| NCBI Gene ID: | 9351 |
| NCBI Accession: | NP_001123484.1 |
| UniProt Secondary Accession: | Q15599,O00272, O00556, Q3KQY7, D3DU84, D3DU85, H3BSV6 |
| UniProt Related Accession: | Q15599 |
| Molecular Weight: | 24,718 Da |
| NCBI Full Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform a |
| NCBI Synonym Full Names: | SLC9A3 regulator 2 |
| NCBI Official Symbol: | SLC9A3R2Â Â |
| NCBI Official Synonym Symbols: | SIP1; OCTS2; SIP-1; TKA-1; E3KARP; NHERF2; NHE3RF2; NHERF-2Â Â |
| NCBI Protein Information: | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 |
| UniProt Protein Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 |
| UniProt Synonym Protein Names: | NHE3 kinase A regulatory protein E3KARP; SRY-interacting protein 1; SIP-1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; Tyrosine kinase activator protein 1; TKA-1 |
| UniProt Gene Name: | SLC9A3R2Â Â |
