The SLC9A3R2 Polyclonal Antibody (PAC020536) is a valuable tool for researchers studying the SLC9A3R2 protein, a member of the sodium/hydrogen exchanger family implicated in ion transport and cell homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SLC9A3R2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and cell physiology.
SLC9A3R2, also known as NHE-RF2, is crucial for maintaining cellular pH and ion balance, as well as regulating intracellular signaling pathways. Its role in ion transport makes it a key player in various cellular processes, making it a promising target for research in areas such as cell biology, physiology, and cancer biology. Studying the function of SLC9A3R2 can provide insights into its potential as a therapeutic target for diseases related to ion transport dysregulation.
Antibody Name:
SLC9A3R2 Antibody (PACO20536)
Antibody SKU:
PACO20536
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Rat
Immunogen:
Synthetic peptide of human SLC9A3R2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20536(SLC9A3R2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms:
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
UniProt Protein Function:
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus.
NCBI Summary:
This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
