The SLC9A3R2 Antibody (PAC020535) is a polyclonal antibody designed for research involving SLC9A3R2, a key protein involved in ion transport and cellular homeostasis. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for Western blot applications. By binding to the SLC9A3R2 protein, this antibody enables the detection and analysis of SLC9A3R2 in various cell types, allowing for research in the fields of cell biology and physiology.SLC9A3R2, also known as NHE-RF2, plays a crucial role in regulating ion transport processes in cells, particularly in maintaining acid-base balance and intracellular pH.
Its involvement in cellular homeostasis makes it a valuable target for research into various diseases and conditions, such as hypertension, renal disorders, and cancer. Understanding the function of SLC9A3R2 is essential for developing targeted therapies that modulate ion transport processes and cellular function in disease settings.
Antibody Name:
SLC9A3R2 Antibody (PACO20535)
Antibody SKU:
PACO20535
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Rat
Immunogen:
Synthetic peptide of human SLC9A3R2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20535(SLC9A3R2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms:
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
UniProt Protein Function:
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus.
NCBI Summary:
This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
