The SLC9A3R1 Polyclonal Antibody (CAB0146) is a valuable tool for researchers investigating the SLC9A3R1 protein, which is involved in the regulation of intracellular pH and ion transport. This antibody, produced in rabbits, exhibits high specificity and sensitivity to human samples, making it ideal for use in Western blot experiments. By targeting the SLC9A3R1 protein, this antibody enables researchers to analyze its expression and function in various cell types, offering valuable insights into cellular physiology and potential therapeutic targets.SLC9A3R1, also known as NHE-RF1, plays a crucial role in maintaining cellular pH and ion balance, which are essential for normal cell function and survival.
Dysregulation of SLC9A3R1 has been implicated in various diseases, including cardiovascular disorders, kidney diseases, and cancer. By studying the activity of SLC9A3R1 using this antibody, researchers can further our understanding of its role in disease pathology and potentially identify novel treatment strategies that target this important protein.Overall, the SLC9A3R1 Polyclonal Antibody (CAB0146) is a reliable tool for research endeavors focused on unraveling the physiological and pathological functions of the SLC9A3R1 protein, offering valuable insights that may have implications for the development of future therapeutic interventions.
Product Name:
SLC9A3R1 Rabbit Polyclonal Antibody
SKU:
CAB0146
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 189-358 of human SLC9A3R1 (NP_004243.1).
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.
Purification Method:
Affinity purification
Gene ID:
9368
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SLC9A3R1 antibody (CAB0146) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
