SLC8B1 Antibody (PACO20486)
- SKU:
- PACO20486
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
SLC8B1 Antibody (PACO20486)
The SLC8B1 Polyclonal Antibody (PAC020486) is a valuable tool for researchers studying SLC8B1, a key protein involved in calcium ion transport and cellular signaling processes. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the SLC8B1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for investigations in the fields of molecular biology and physiology.
SLC8B1, also known as NCLX, plays a crucial role in maintaining cellular calcium homeostasis, which is essential for normal cell function and survival. Dysregulation of SLC8B1 has been associated with various diseases, including cardiac disorders and neurodegenerative conditions. Research into the function and regulation of SLC8B1 is vital for understanding its role in health and disease, and may lead to the development of targeted therapies for conditions related to calcium signaling imbalance.
| Antibody Name: | SLC8B1 Antibody (PACO20486) |
| Antibody SKU: | PACO20486 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human SLC8B1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20486(SLC8B1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE,Lysate: 40 µg,Lane 1-2: Human placenta tissue, Human normal kidney tissue,Primary antibody: PACO20486(SLC8B1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20486(SLC8B1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion. |
| Synonyms: | solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 |
| UniProt Protein Function: | Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069). |
| UniProt Protein Details: | |
| NCBI Summary: | SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6J4K2 |
| NCBI GenInfo Identifier: | 1060099165 |
| NCBI Gene ID: | 80024 |
| NCBI Accession: | NP_001317395.1 |
| UniProt Secondary Accession: | Q6J4K2,Q4KMS9, Q6J4K1, Q9H6I8, A6NP50 |
| UniProt Related Accession: | Q6J4K2 |
| Molecular Weight: | 58,087 Da |
| NCBI Full Name: | mitochondrial sodium/calcium exchanger protein isoform 2 |
| NCBI Synonym Full Names: | solute carrier family 8 member B1 |
| NCBI Official Symbol: | SLC8B1Â Â |
| NCBI Official Synonym Symbols: | NCLX; NCKX6; SLC24A6Â Â |
| NCBI Protein Information: | mitochondrial sodium/calcium exchanger protein |
| UniProt Protein Name: | Mitochondrial sodium/calcium exchanger protein |
| UniProt Synonym Protein Names: | Na(+)/K(+)/Ca(2+)-exchange protein 6 |
| Protein Family: | |
| UniProt Gene Name: | SLC8B1Â Â |
| UniProt Entry Name: |
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