The SLC8B1 Polyclonal Antibody (PAC01258) is a specialized research tool designed for studying SLC8B1, a sodium/calcium exchanger protein involved in ion transport and cellular signaling processes. This antibody, generated in rabbits, exhibits high reactivity towards human samples and is validated for Western blot applications. By targeting the SLC8B1 protein, this antibody facilitates the detection and analysis of SLC8B1 expression in various cell types, making it an ideal tool for researchers in the fields of physiology, neuroscience, and cardiovascular research.
SLC8B1, also known as the sodium/calcium exchanger 1, plays a crucial role in maintaining cellular calcium homeostasis and regulating intracellular signaling cascades. Dysregulation of SLC8B1 function has been implicated in various pathological conditions such as cardiovascular diseases, neurodegenerative disorders, and cancer. Studying the role of SLC8B1 with this antibody can provide valuable insights into the mechanisms underlying these diseases and potentially lead to the development of novel therapeutic strategies targeting SLC8B1 activity.
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6;SLC24A6;FLJ22233;NCKX6;NCLX ;
UniProt Protein Function:
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069).
UniProt Protein Details:
NCBI Summary:
SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
