The SLC8A3 Polyclonal Antibody (CAB18381) is specifically designed for research involving the SLC8A3 protein, a member of the Solute Carrier family known to play a role in calcium regulation in cells. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the SLC8A3 protein, this antibody allows for detection and analysis in various cell types, making it an ideal tool for studies focused on cellular calcium homeostasis and its implications in various physiological processes.SLC8A3, also known as sodium/calcium exchanger 3, is a key player in calcium signaling pathways within cells, influencing processes such as muscle contraction, neuronal activity, and cell proliferation.
Dysregulation of calcium homeostasis has been implicated in various diseases, including cardiovascular disorders, neurodegenerative diseases, and cancer. Understanding the function and regulation of SLC8A3 can provide valuable insights into these pathologies and aid in the development of targeted therapies.Overall, the SLC8A3 Polyclonal Antibody is a critical tool for researchers studying calcium signaling pathways and their implications in disease states, offering high specificity and sensitivity for the detection and analysis of SLC8A3 protein levels in experimental samples.
Product Name:
SLC8A3 Rabbit Polyclonal Antibody
SKU:
CAB18381
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 550-650 of human SLC8A3 (NP_489479.1).
axon, axon terminus, dendrite, dendritic spine, neuromuscular junction, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynapse, postsynaptic density, synapse
Calculated MW:
103kDa
Observed MW:
110kDa
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described.
Purification Method:
Affinity purification
Gene ID:
6547
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC8A3 Rabbit pAb (CAB18381) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 120s.
