SLC8A1 Rabbit Polyclonal Antibody (CAB5583)
- SKU:
- CAB5583
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Product Name: | SLC8A1 Rabbit Polyclonal Antibody |
SKU: | CAB5583 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-700 of human SLC8A1 (NP_066920.1). |
Sequence: | DEIV KTIS VKVI DDEE YEKN KTFF LEIG EPRL VEMS EKKA LLLN ELGG FTIT GKYL FGQP VFRK VHAR EHPI LSTV ITIA DEYD DKQP LTSK EEEE RRIA E |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:2000 - 1:6000 IHC-P,1:50 - 1:200 |
Synonyms: | NCX1; SLC8A1 |
Positive Sample: | 293T,RD,SH-SY5Y,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 109kDa |
Observed MW: | 100kDa |
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.
Purification Method: | Affinity purification |
Gene ID: | 6546 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |