The SLC7A11 Polyclonal Antibody (CAB13685) is a crucial tool for research involving SLC7A11, a key component of the cystine/glutamate antiporter system, involved in regulating cellular redox balance and protecting cells from oxidative stress. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It specifically binds to the SLC7A11 protein, allowing for accurate detection and analysis in a variety of cell types, making it an essential resource for studies in cell biology, cancer research, and pathophysiology.
SLC7A11 plays a crucial role in maintaining cellular redox homeostasis by mediating the exchange of cystine for glutamate, which is essential for the synthesis of glutathione, a major antioxidant in cells. Dysregulation of SLC7A11 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes, highlighting its potential as a therapeutic target. Understanding the function and regulation of SLC7A11 is vital for advancing research in these areas and developing targeted interventions to combat oxidative stress-related pathologies.
Product Name:
SLC7A11/xCT Rabbit Polyclonal Antibody
SKU:
CAB13685
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC7A11/xCT (NP_055146.1).
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
Purification Method:
Affinity purification
Gene ID:
23657
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain using SLC7A11/xCT Rabbit pAb(CAB13685) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
