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SLC6A5 Rabbit Polyclonal Antibody (CAB11647)

SKU:
CAB11647
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Neuroscience
€139 - €419

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:SLC6A5 Rabbit Polyclonal Antibody
SKU:CAB11647
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SLC6A5 (NP_004202.3).
Sequence:MDCS APKE MNKL PANS PEAA AAQG HPDG PCAP RTSP EQEL PAAA APPP PRVP RSAS TGAQ TFQS ADAR ACEA ERPG VGSC KLSS PRAQ AASA ALRD LREA QGAQ ASPP PGSS GPGN ALHC KIPF LRGP EGDA NVSV GKGT LERN NTPV VGWV NMSQ STVV LGTD GITS VLPG SVAT VATQ EDEQ GDEN KARG NWSS KLDF
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:NET1; GLYT2; HKPX3; GLYT-2; SLC6A5
Positive Sample:SH-SY5Y,U-937,U-87MG,U-251MG,Mouse brain,Mouse liver,Rat brain
Conjugate:Unconjugated
Cellular Localization:Membrane, Multi-pass membrane protein.
Calculated MW:87kDa
Observed MW:60kDa

This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:9152
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using SLC6A5 Rabbit pAb (CAB11647) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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