The SLC6A4 Polyclonal Antibody (CAB14171) is a valuable tool for researchers studying the SLC6A4 gene, which encodes the serotonin transporter protein. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and is suitable for use in Western blot applications. By targeting the SLC6A4 protein, this antibody allows for the detection and analysis of serotonin transporter levels in various cell types, providing insights into neurotransmission and psychiatric disorders.The serotonin transporter, encoded by the SLC6A4 gene, is essential for regulating serotonin levels in the brain and plays a critical role in mood, emotion, and behavior.
Dysregulation of the serotonin transporter has been implicated in various psychiatric disorders, including depression, anxiety, and obsessive-compulsive disorder. By studying the expression and function of SLC6A4, researchers can gain a better understanding of the underlying mechanisms of these conditions and potentially identify new therapeutic targets for treatment.
Product Name:
Serotonin transporter Rabbit Polyclonal Antibody
SKU:
CAB14171
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-84 of human Serotonin transporter (NP_001036.1).
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression.
Purification Method:
Affinity purification
Gene ID:
6532
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using Serotonin transporter Rabbit pAb (CAB14171) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
