The SLC6A3 Polyclonal Antibody (CAB15236) is specifically designed for research involving SLC6A3, a crucial neurotransmitter transporter responsible for the reuptake of dopamine from the synaptic cleft. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it a valuable tool for studying the function and regulation of SLC6A3 in various experimental settings.SLC6A3, also known as the dopamine transporter (DAT), plays a key role in regulating dopamine levels in the brain, influencing behaviors related to reward, motivation, and movement control. Dysregulation of SLC6A3 function has been associated with neurological disorders such as Parkinson's disease, attention deficit hyperactivity disorder (ADHD), and substance abuse disorders.
By targeting SLC6A3 with this antibody, researchers can gain insight into the molecular mechanisms underlying these conditions and potentially identify therapeutic interventions.In addition to its applications in neuroscience research, the SLC6A3 Polyclonal Antibody is also suitable for use in immunohistochemistry, immunofluorescence, and flow cytometry assays, allowing for versatile detection and localization of SLC6A3 in various cell types and tissues. With its reliability and versatility, this antibody is a valuable resource for advancing our understanding of dopamine regulation and its implications for human health and disease.
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
Purification Method:
Affinity purification
Gene ID:
6531
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using Dopamine Transporter/SLC6A3 Rabbit pAb (CAB15236) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
