The SLC6A2 Monoclonal Antibody is a specialized tool for researchers studying SLC6A2, a protein involved in neurotransmitter transport, specifically in the regulation of the neurotransmitter norepinephrine. This antibody, generated in mice, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot analyses.SLC6A2, also known as the norepinephrine transporter, plays a crucial role in neuronal signaling by facilitating the reuptake of norepinephrine from the synaptic cleft. Dysregulation of SLC6A2 has been implicated in various neurological disorders, including depression, anxiety, and attention-deficit hyperactivity disorder (ADHD).
By targeting SLC6A2, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets.With its ability to accurately detect and quantify SLC6A2 expression in a variety of cell types, the SLC6A2 Monoclonal Antibody is an invaluable tool for researchers seeking to deepen their understanding of neurotransmitter transport and its implications for neurological health. Whether studying basic neurobiology or searching for new drug targets, this antibody provides a reliable means of investigating the role of SLC6A2 in physiological and pathological conditions.
Product Name:
SLC6A2 Monoclonal Antibody
SKU:
CAB22765
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human SLC6A2(NP_001034.1).
This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Purification Method:
Affinity purification
Gene ID:
6530
Clone Number:
ARC58596
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SLC6A2 Rabbit mAb (CAB22765) at 1:16000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
